The Armenian captain and Manchester united midfielder is becoming an increasingly important cog in Mourinho's United side, and scored the opener in their 3-0 win over Leicester City on Sunday.
Thereafter United were irresistible, with Mkhitaryan and Juan Mata in particular picking Leicester apart easily as the visitors scored three goals in seven minutes either side of halftime.
No team has ever gone down a year after winning the title in the Premier League era.
Where Arsenal and Liverpool look devoid of a "Plan B" if their slick, quick-passing style fails, sixth-placed United can successfully adapt if their initial plans prove fruitless. That's only one-point clear of 18th place Hull City, a team that has managed two results against top six teams in the last week and have completely turned things around since hiring Marco Silva.
United thrashed Leicester City 3-0 away from home, while City had to work harder than expected to beat Swansea 2-1. It is over and if you get a player from these clubs, you get a player that club does not want to keep.
Elsewhere, some United fans feared they might have seen the last of Marouane Fellaini's trademark haircut after he posted a picture of himself apparently getting ready for a haircut on social media earlier this week. Today we did and that made the difference.
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During the phone call , Trump reportedly said that it was "the worst by far" of his multiple calls with world leaders that day. He also publicly highlighted Australia's long history with United States troops in wars across the world.
The report claims that Martial has plummeted down the pecking order at United, with Jesse Lingard, Henrikh Mkhitaryan, Juan Mata and Marcus Rashford ahead of him. It is unknown whether Mourinho would revert to the 4-4-2 formation he picked in the first-half at Leicester, but nevertheless, the pair will be definite starters.
And Mourinho was pleased his players showed a cutting edge they have been lacking in recent months to kill the game off before half-time. If they don't believe in me, they have to do only one thing, and that is go to the chairman and tell them they don't believe, please change.
Goal-line technology would rule out such an error these days, but other decisions could easily go for or against Leicester on the final day of the season this year.
"If we had won our games and got the points we should have got then the situation would be totally different but okay, we look at the other teams and hopefully they lose points". You secure that many points and you feel good about your chances of staying up.
It was a warning Leicester failed to heed and United took the lead in the 42nd minute when Mkhitaryan punished a mistake from Robert Huth.
Jamie Vardy had 24 goals last season.