This is far from an easy game, but it is one that Antonio Conte will be expecting a win.
Chelsea have endured few injury problems this season and the entire squad is expected to be available for the game at Stamford Bridge. They've all been played in London.
As West Ham are now out of the relegation battle in ninth place and trail seventh placed Everton by 11 points, they could be forgiven for being content with what they have achieved this season -especially considering their poor star. Conte has revived the team to take a commanding lead at the summit. But he will surely be forearmed after experiencing first hand what West Ham can be capable of on their day.
West Ham's Aaron Cresswell has said that his club are aiming to finish as high as possible this season, which should come as a warning to Chelsea - whom the Hammers face on Monday.
Listen to live coverage of West Ham v Chelsea on BBC Radio 5 live, with commentary from John Murray and Phil Neville.
"It is right that Victor Moses deserves a new contract". His pace, quality on the ball and stamina is basically top, top-class. "If you ask me if I imagined him in this new position, no".
"I remember once I spoke to [Dimitri] Payet during last season".
"This game against West Ham, for us, is very important", Conte said.
Stephenson was hugely impressed with Antonio Conte's Chelsea side, adding: "Chelsea are a quality side in fantastic form, playing with pace and displaying quality and skill".
Fernando Torres in a "stable" condition following head clash
Players from both sides immediately called for medical attention when Torres hit the ground. Torres had entered the game as a substitute for Kevin Gameiro 20 minutes earlier.
"Delighted to have signed a new contract with Chelsea FC". It's nice to have options it's nice that other clubs have a good opinion about you. It's unfortunate for Michail Antonio that he will miss the game through suspension as he is probably vying for the Player of the Season accolade now; the team will miss his speed and direct running.
Moses has enjoyed a fine campaign for the Blues, impressing at wing-back after previous seasons out on loan at West Ham, Stoke and Liverpool. "He got kicked. But it's nothing serious", Conte told reporters.
Think you can do better than Lawro?
Last season's debacle is a near distant memory but Conte is fully aware that whilst the Blues remain on course for a fifth Premier League title, testing himself against Europe's best is a completely different proposition altogether.
However, manager Antonio Conte started that game without Eden Hazard, Diego Costa and Pedro and when those three players were introduced in the second half with the Hammers already 2-0 up, the tide of the match changed dramatically.
Cesc Fabregas recorded his 102nd Premier League assist in what was his 300th Premier League game last weekend.
Belgian global Thibaut Courtois is a certain starter to start for the Blues having been ever-present in the Premier League. However, the Blues have become so functional in their play as of late and will subsequently have enough to edge an intriguing contest.
Andy Carroll has scored five goals in his last three home London derbies in the Premier League.
Probability of away win: 53%.