Rafa Benitez' side had a hard start in their campaign opener at St. James' Park after the Magpies were forced to make two defensive substitutions within the first half of the 2-0 loss to title contenders Spurs.
Notoriously sluggish at the start of the season, Spurs were playing at a lazy tempo, with only debutant Kyle Walker-Peters - a replacement for his near-namesake Kyle Walker on the visitors' right side - and Christian Eriksen showing any invention or energy.
To make matters worse, Newcastle were already relegated and played the last 23 minutes with 10 men.
Sissoko was taken off after 57 minutes, a tactical swap for Son Heung-min, and within three minutes Spurs took the lead.
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Newcastle's cause wasn't helped by losing defenders Paul Dummett and Florian Lejeune - the 200th French player to feature in a Premier League game - to injury in the first half. Subs: Darlow, Lascelles, Mbemba, Murphy, Aarons, Merino, Mitrovic.
Manchester City kicked off their English Premier League (EPL) football season with a 2-0 away victory over newly promoted Brighton & Hove Albion at the American Express Community Stadium. I think this season, they do have a team. He is so calm, is so courageous and I think then he scored, a great goal and I'm very happy. They were fantastic last year supporting the team and they will be the same this year.
"It will be a tough test against Tottenham, you are talking about one of the best teams in the division".