Victor Moses inspired Nigeria to take a step closer to World Cup qualification on Friday but Cameroon, Ghana and South Africa suffered serious blows to their chances of reaching next year's finals in Russian Federation.
With Cameroon looking deflated, the Eagles had more time to add another goal, through substitute Kelechi Iheanacho.
One of Ghana's best efforts in the first half came from Atletico Madrid's Thomas Partey who forced a good save by Congo goalkeeper Barel Mouko from a long-range effort.
Cameroon's fightback in the second half was feeble in the face of the commanding Nigerian defense line which had Leon Balogun all over and William Troost-Ekong stifling the opponents play.
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Nigeria's national football team have already gained nine points, the highest in a group that consists of their recent opponent, Algeria and Zambia.
The Eagles are now unbeaten in 33 World Cup qualifying games.
"I am not afraid of a sack and I don't think about that", he said after the game. "We dedicate this win to Carl; I am sure he will be very happy about this".
The Super Eagles surged ahead with support from a home crowd, as they played in Uyo.
The 28-year-old Beijing 2008 Olympic Games silver medalist, who made several saves to deny the Indomitable Lions a chance of coming back into the game, said team work made the win possible. "We will enjoy this victory, sleep over it and then by tomorrow morning, we can start thinking about the match in Yaounde on Monday".