"Twelve people died of poisoning from carbon monoxide" in the fire at the Leogrand hotel, a hotel of 22 floors, has declared to the press, the regional minister of Health, Zaal Mikeladze.
The cause of the fire, which has since been put out, is not clear.
Most of the guests being treated for injuries are said to be Turkish and Israeli.
Another 21 people required hospitalization, the ministry said.
Prime Minister Giorgi Kvirikashvili, who stopped off in Batumi on his way back from a trip to Brussels, said that those responsible for the disaster would be severely punished.
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More than 100 people were evacuated from the hotel by emergency services. According to officials, no participants of the contest, who were staying at the hotel, were injured in the blaze.
The hotel was due to host the Miss Georgia beauty pageant on Sunday. Ten of them were Georgian citizens and one - Iranian, the Interior Ministry said.
In a later post he offered his condolences the families and promised an investigation to find the fire's causes.
The fire at the Leogrand Hotel broke out on Friday evening.